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Oncology Intelligence

Mechanisms of Action Oncology Pharmaceuticals
Growth-based MOAs: Growth Factors and Receptors
Growth Hallmark MOA
Growth Hallmark Indication
EGFR/HER
cMET
FGF
FLT3
IGFR
cKIT
WNT
TGF
Angiogenesis-based MOAs
AngiogenesisHallmark_122714
angiogenesis_indication_1715
VEGF
mTOR
VDA/VTA
PDGF
Notch/DLL4
Ang/TIE
MapK
S1P
TSP-1
Apoptosis-based MOAs
ApoptosisHallmark_122714
apoptosis_indication_1715
TNF
Akt/PI3K
IAPs
PARP
Bcl-2
NFκB
Trk
Motility-based MOAs
MotilityHallmark_122714
motility_indication_1715
HDAC
Jaks/Stat
INT
FAK
Pgp-1
Genome Instability-based MOAs
GenomeHallmark_122714
genome_indication_1715
Aurora
CDK
RXR
ALK
p53
PKC
Proliferation-based MOAs
ProliferationHallmark_122714
proliferation_indication_1715
BRAF
Src
Hh/SMO
RAS
Immortality-based MOAs
ImmortalityHallmark_122714
immortality_indication_1715
HSP
Bcr-Abl
PLK
telomerase
Energy Metabolism-based MOAs
EnergyHallmark_122714
energy_indication_1715
HIF
ROS
P-gp